CRM: Centro De Giorgi
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Reverse mathematical methods for reconstructing molecular dynamics in single cell

Multistate modelling and parameter inference for particle tracking analysis and super-resolution imaging of immune cell surface receptors

speaker: Daniel Coombs (University of British Columbia (UBC), Canada)

abstract: T and B cells of the immune system detect and respond to foreign invaders using surface bound receptor molecules. These molecules can be labelled and their motion tracked on an individual basis on live cells, or their positions can be determined en masse and at extraordinary resolution on fixed cells. I will present recent work on quantitative methods for studying single receptor motion. I will also talk about our efforts to assess and quantify receptor clustering, based on super-resolution microscopy experiments.

Tue 16 Oct, 15:15 - 16:00, Aula Dini
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